Terpenoids from the Soft Coral <i>Stereonephthya bellissima</i>

A detailed chemical study of the extract from the soft coral Stereonephthya bellissima resulted in the isolation and identification of seven new sesquiterpenoids, bellissinanes A–G (1–7), along with four new diterpenes (8–11). Bellissinane A (1) is the third reported nardosinane-type sesquiterpene bearing a 6/5/6 tricyclic system. Bellissinanes C and D (3, 4) contain a phenylethylamine fragment, which is relatively unusual in marine organisms. Bellissinanes E–G (5–7) belong to the rare class of nornardosinane sesquiterpenoids. Structurally uncommon octahydro-1H-indenyl-type and prenyleudesmane-type skeletons were characterized for herpetopanone B (8) and bellissimain A (9), respectively. Bellissinane E (5) exhibited in vivo angiogenesis-promoting activity.针对软珊瑚（soft coral）*Stereonephthya bellissima*的提取物开展的详尽化学研究，成功分离并鉴定出7个全新倍半萜类化合物（sesquiterpenoids）：bellissinanes A~G（1~7），同时得到4个全新二萜类化合物（diterpenes，8~11）。 Bellissinane A（1）是目前已报道的第3个具有6/5/6三环体系（tricyclic system）的纳多辛烷型（nardosinane-type）倍半萜。 Bellissinanes C与D（3、4）含有苯乙胺片段（phenylethylamine fragment），这类结构在海洋生物（marine organisms）中较为少见。 Bellissinanes E~G（5~7）隶属于罕见的去甲纳多辛烷型（nornardosinane）倍半萜类化合物类群。 结构上较为特殊的八氢-1H-茚型（octahydro-1H-indenyl-type）与异戊二烯基桉叶烷型（prenyleudesmane-type）骨架，分别为herpetopanone B（8）与bellissimain A（9）所具有。 Bellissinane E（5）展现出体内（in vivo）促血管生成活性（angiogenesis-promoting activity）。