FInnish National Protein Crystallography Consortium

The Finnish BAG encompasses 24 groups active in crystallography in Finland. The projects vary widely and include membrane proteins and protein complexes, other proteins involved in disease and antibiotics and drug development and discovery (ADP-ribosylation and several oncogenic proteins including kinases, biocatalysis, endoplasmic regulation and protein secretion) and several pathogen proteins and various enzyme targets and e.g. studies on phytochrome photoreceptors and complexes involved in actin dynamics regulation as well as membrane protein targets. Overall the BAG serves the national needs for highly variable projects, with different biological and biotechnological applications. Several project will benefit from microfocus beam lines and tunable wavelength options, others benefit from quick robust screening by MASSIF.

芬兰BAG（Finnish BAG）涵盖了芬兰国内24个活跃于晶体学领域的研究团队。该机构的研究项目覆盖范围极广，包括膜蛋白与蛋白复合物、参与疾病及抗生素研发、药物开发与发现过程的其他蛋白（如ADP-核糖基化（ADP-ribosylation）相关蛋白、多种致癌蛋白如激酶（kinases）、生物催化相关蛋白、内质网调控与蛋白分泌相关蛋白）、多种病原蛋白与各类酶靶点，以及针对植物色素光受体（phytochrome photoreceptors）、肌动蛋白动态调控（actin dynamics regulation）相关复合物与膜蛋白靶点的研究。总体而言，芬兰BAG可满足国内多样化研究项目的需求，覆盖各类生物学与生物技术应用场景。部分项目将受益于微聚焦光束线与可调波长选项，其余项目则可通过MASSIF系统实现高效稳定的筛选流程。