Joint association results (p-values) of the non-corresponding genetic risk score with each lipid outcome controlling for the corresponding genetic risk score.

For example, we can determine the contribution of non-HDL genetic risk scores to HDL above and beyond the HDL genetic risk score by testing the full model: HDL ~ HDL GRS + LDL GRS + TC GRS + TG GRS; against the reduced model: HDL ~ HDL GRS.

举例而言，我们可通过对完整模型与简约模型开展假设检验，明确非高密度脂蛋白（non-High-Density Lipoprotein, non-HDL）遗传风险评分（genetic risk score, GRS）相较于高密度脂蛋白（High-Density Lipoprotein, HDL）遗传风险评分，对HDL水平的额外增量贡献：完整模型设定为 HDL ~ HDL GRS + LDL GRS + TC GRS + TG GRS；简约模型设定为 HDL ~ HDL GRS。