Data from: Feasibility of a blended group intervention (bGT) for major depression: uncontrolled interventional study in a university setting

Objective: This study investigated the feasibility of a novel blended (face-to-face and computer-based) group intervention for the reduction of depressive symptoms in major depression. Design: Patient-centred uncontrolled interventional study. Setting: University setting in a general community sample. A multi-modal recruitment strategy (public health centres and public areas) was applied. Participants: Based on independent interviews, 26 participants, diagnosed with major depressive disorder (81 % female; 23 % comorbidity > 1, 23 % comorbidity > 2), entered treatment. Intervention: Acceptance and mindfulness-based, as well as self-management and resource-oriented psychotherapy principles served as the theoretical basis for the low-threshold intervention. The blended format included face-to-face sessions, complemented with multimedia presentations and a platform featuring videos, online work sheets, an unguided group-chat, as well as remote therapistpatient communication. Main outcome measures: The Center for Epidemiological Studies-Depression scale (CES-D) and the twelve-item General Health Questionnaire (GHQ-12). Results: Large to very large within group effect sizes were found on self-reported depression (F(2, 46.37)=25.69, p < .001; d = 1.80), general health (F(2,46.73)= 11.47, p < .001; d = 1.32), personal resources (F(2,43.36)= 21.17, p < .001; d = 0.90) and mindfulness (F(2,46.22)= 9.40, p < .001; d = 1.12) after a follow-up period of three months. Treatment satisfaction was high and 69 % ranked computer and multimedia use as a therapeutic factor. Furthermore, participants described treatment intensification as important advantage of the blended format. Half of patients (48 %) would have preferred more time for personal exchange. Conclusion: The investigated blended group format seems feasible for the reduction of depressive symptoms in major depression. The development of blended interventions can benefit from assuring that highly structured treatments actually meet patients’ needs. As a next step, the intervention should be tested in comparative trials in routine care. Trial registration: DRKS-ID: DRKS00010894

研究目的：本研究探讨一种新型混合式（面对面与计算机辅助）团体干预手段用于减轻重度抑郁障碍（major depressive disorder）患者抑郁症状的可行性。
研究设计：以患者为中心的非对照干预性研究。
研究场景：基于普通社区人群的大学研究场景，采用多模式招募策略（公共卫生中心与公共区域）。
研究对象：经独立访谈筛选后，共26名被诊断为重度抑郁障碍的受试者（女性占81%；共病1种以上者占23%，共病2种以上者占23%）入组接受治疗。
干预方案：本低门槛干预的理论基础为接纳与正念取向、自我管理及资源导向的心理治疗原则。混合式干预形式包含面对面团体环节，并辅以多媒体演示，以及搭载视频、在线工作表、非指导式团体聊天、远程医患沟通功能的线上平台。
主要结局指标：采用流行病学研究中心抑郁量表（Center for Epidemiological Studies-Depression scale, CES-D）与12项一般健康问卷（twelve-item General Health Questionnaire, GHQ-12）进行评估。
结果：在为期3个月的随访期后，受试者自我报告的抑郁症状（F(2, 46.37)=25.69, p < .001; d = 1.80）、一般健康状况（F(2,46.73)= 11.47, p < .001; d = 1.32）、个人资源（F(2,43.36)= 21.17, p < .001; d = 0.90）及正念水平（F(2,46.22)= 9.40, p < .001; d = 1.12）均出现组内大至极大的效应量。受试者对治疗的满意度较高，其中69%的受试者认为计算机与多媒体应用是一项治疗获益因素。此外，受试者认为强化治疗是混合式干预形式的重要优势。有半数受试者（48%）希望能拥有更多的人际交流时间。
结论：本研究探讨的混合式团体干预形式在减轻重度抑郁障碍患者抑郁症状方面具备可行性。混合式干预方案的开发可通过确保高度结构化的治疗方案切实贴合患者需求而获得优化。下一步研究应在常规诊疗场景下开展对照试验对该干预手段进行验证。
试验注册：DRKS编号：DRKS00010894