Prevalence of Metabolic Syndrome in Three Regions in Venezuela: The VEMSOLS Study

Abstract Background: No previous study has evaluated the prevalence of metabolic syndrome (MS) in more than one region in Venezuela. Objective: To determine the prevalence of MS in three Venezuelan regions. Methods: From 2006 to 2010, a total of 1,320 subjects aged ≥ 20 years were selected by multistage stratified random sampling from the regions of Lara State (western region), Mérida State (the Andean region), and Capital District (Capital Region). Anthropometric measurements, blood pressure, and biochemical analysis were obtained from each participant. MS was defined according to the harmonized Joint Interim Statement (2009) definition. Results: Mean age was 44.8 ± 0.39 years and 68.5% of the participants were female. The overall prevalence of MS was 35.7% (95% confidence interval 32.2 - 39.2%), while the prevalence was 42.5% (95% CI 38.8 - 46.1%) among men and 32.6% (95% CI 29.1 - 36.0%) among women (p < 0.001). In women, the prevalence of MS increased at almost every decade of life, while in men, the prevalence was similar from the age of 30 years onwards. The most prevalent abnormalities were low HDL-c levels (58.6%, 95% CI 54.9 - 62.1%), abdominal obesity (52.0%, 95% CI 48.4 - 55.7%), and elevated triglycerides levels (39.7%, 95% CI 36.1 - 43.2%). The prevalence of MS increased with increasing body mass index categories. Conclusion: In Venezuela, MS is a highly prevalent condition, which increases the risk of type 2 diabetes and cardiovascular disease in a large number of subjects. (Int J Cardiovasc Sci. 2018; [online].ahead print, PP.0-0)

研究背景：此前尚无研究在委内瑞拉多个地区评估代谢综合征（metabolic syndrome, MS）的患病率。
研究目的：明确委内瑞拉三个地区的代谢综合征患病率。
研究方法：2006年至2010年间，采用多阶段分层随机抽样方法，从拉拉州（西部地区）、梅里达州（安第斯地区）及首都特区（首都地区）共招募1320名年龄≥20岁的受试者。对每名受试者开展人体测量、血压检测及生化分析。代谢综合征的诊断采用统一的联合临时声明（Joint Interim Statement, 2009）标准。
研究结果：受试者平均年龄为44.8±0.39岁，其中68.5%为女性。代谢综合征总体患病率为35.7%（95%置信区间（confidence interval, CI）32.2 - 39.2%）；男性患病率为42.5%（95%置信区间38.8 - 46.1%），女性患病率为32.6%（95%置信区间29.1 - 36.0%），组间差异具有统计学意义（p < 0.001）。女性的代谢综合征患病率几乎随每十年年龄增长而升高，而男性在30岁及以上年龄段的患病率趋于平稳。最常见的代谢异常为高密度脂蛋白胆固醇（high-density lipoprotein cholesterol, HDL-c）水平降低（58.6%，95%置信区间54.9 - 62.1%）、腹型肥胖（52.0%，95%置信区间48.4 - 55.7%）及甘油三酯水平升高（39.7%，95%置信区间36.1 - 43.2%）。代谢综合征患病率随体质量指数分级升高而增加。
研究结论：在委内瑞拉，代谢综合征为高患病率疾病，可使大量受试者罹患2型糖尿病及心血管疾病的风险升高。
（《国际心血管科学杂志》2018年；[在线预印版，页码0-0]）