DATA.pdf

Data are in PDF format. This study focused on the cognitive function of women with type 1 diabetes in pregnancy. We investigated risk factors for a low cognitive score as age, duration of Diabetes, BMI, subclinical hypothyroidism, cardiovascular autonomic neuropathy, the impact of hypo-/hyperglycemia, and C-peptide preservation. Material and methods. Seventy-eight pregnant women with type 1 diabetes (age 31.1±5.4 years, diabetes duration 14.3±8.9 years) were included in the study. Cognitive function was assessed in different domains, such as reasoning, memory, attention, coordination, and perception. Results. The cognitive test values ≥400 were considered high scores, and values <400 were considered low. Relative risks for low scores for general cognitive function are associated with increased BMI >25 kg/m2 2.208 (95% CI 1.116-4.370), HbA1c >6.5% RR 0.774 (95% CI 0.366-1.638), subclinical hypothyroidism RR 3.111 (95% CI 1.140-8.491), impaired cardiovascular autonomic neuropathy RR 2.250 (95% CI 1.000-5.062) CGM glucose values >7.8 RR 1.875 (95% CI 0.757-4.642), and CGM glucose values <3.9 RR 0.938 (95% CI 0.346-2.539). In women with C-peptide preservation in 1st trimester RR 0.297 (95% CI 0.097-0.912, p=0.034). Conclusion. BMI >25 kg/m2, subclinical hypothyroidism, and cardiovascular autonomic neuropathy are associated with increased risk and postprandial C-peptide preservation with reduced risk for cognitive impairment in pregnant women with type 1 diabetes.

本数据集采用PDF格式存储。本研究聚焦于妊娠合并1型糖尿病女性的认知功能，探讨了认知评分偏低的相关危险因素，包括年龄、糖尿病病程、体质量指数（BMI）、亚临床甲状腺功能减退症、心血管自主神经病变、高低血糖的影响以及C肽保留情况。
对象与方法：本研究共纳入78例妊娠合并1型糖尿病女性，受试者年龄为31.1±5.4岁，糖尿病病程为14.3±8.9年。采用多维度评估方式对受试者的认知功能进行测评，涵盖推理能力、记忆力、注意力、协调能力与感知能力等领域。
结果：本研究将认知测试得分≥400定义为高分，得分<400定义为低分。整体认知功能低分的相对风险如下：体质量指数>25 kg/m²的相对风险为2.208（95%置信区间[CI]：1.116~4.370）；糖化血红蛋白（HbA1c）>6.5%的相对风险为0.774（95%CI：0.366~1.638）；亚临床甲状腺功能减退症的相对风险为3.111（95%CI：1.140~8.491）；合并心血管自主神经病变的相对风险为2.250（95%CI：1.000~5.062）；持续葡萄糖监测（CGM）显示血糖>7.8的相对风险为1.875（95%CI：0.757~4.642）；CGM监测血糖<3.9的相对风险为0.938（95%CI：0.346~2.539）。在妊娠早期保留C肽的女性中，相对风险为0.297（95%CI：0.097~0.912，p=0.034）。
结论：体质量指数>25 kg/m²、亚临床甲状腺功能减退症及心血管自主神经病变与妊娠合并1型糖尿病女性的认知损伤风险升高显著相关，而餐后C肽保留则可降低该类人群的认知损伤风险。