Hybrid nanozymes with synergetic catalytic activity as antimicrobial agents

Antimicrobial resistance (AMR) is an escalating global health crisis, with projections indicating it could cause up to 39 million deaths over the next 25 years, equivalent to more than three deaths every minute. My research focuses on the development of hybrid nanozymes, which are nanoparticles engineered to mimic natural enzymes and generate reactive oxygen molecules capable of destroying bacteria, including drug-resistant strains. By integrating metals and metal oxides, these hybrid nanozymes leverage a synergistic effect to amplify their catalytic and antimicrobial activity. This approach offers a promising, and cost-effective alternative to traditional antibiotics in the ongoing fight against resistant pathogens.

抗菌药物耐药性（Antimicrobial resistance, AMR）正演变为日益严峻的全球性公共卫生危机。据预测，未来25年内其或造成多达3900万人死亡，相当于每分钟超过3人因此殒命。本研究聚焦于混合纳米酶（hybrid nanozymes）的开发：这类经工程改造的纳米颗粒可模拟天然酶功能，产生活性氧分子，能够杀灭包括耐药菌株在内的各类细菌。通过整合金属与金属氧化物，此类混合纳米酶可借助协同效应增强其催化活性与抗菌效能。在对抗耐药病原体的持续斗争中，该方案为传统抗生素提供了一种极具前景且成本效益优异的替代选择。