Studies toward the Total Synthesis of Wiedemannic Acid

We report a novel and efficient diastereoselective synthesis of wiedemannic acid analogue 30 in 16 steps from 7 using a tandem oxy-Cope/Claisen/ene reaction as the key step. Comparison of NMR data between wiedemannic acid (1) and analogue 30 leads us to believe that the
reported stereochemistry at the ring junction of 1 is incorrect.

我们报道了一种新颖且高效的非对映选择性合成方法，以串联氧杂Cope/Claisen/ene反应为关键步骤，从化合物7出发经16步反应制备得到维德曼酸（Wiedemannic acid）类似物30。通过对比维德曼酸（1）与类似物30的核磁共振（NMR）数据，我们认为此前所报道的化合物1的环接合位点立体化学构型存在错误。