Association of ADH1B genotype with risk of upper aerodigestive cancer.

Risk of upper aerodigestive cancer by ADH1B genetic variation, stratified by drinking intensity and smoking status, is shown as the odds ratio (OR) of upper aerodigestive cancer by re1229984 (ADH1B) genotype comparing rare allele (dominant model) carriers versus common allele homozygous genotype. ORs are standardised by age, sex, study centre, cumulative alcohol consumption, and, when relevant, smoking. ORs and 95% CI are derived from fixed effects models. Figure adapted from Hashibe et al. (2008) [57] with permission granted by Nature Publishing Group.

本数据集展示了按饮酒强度与吸烟状态分层的、与乙醇脱氢酶1B（ADH1B）遗传变异相关的上呼吸消化道癌发病风险，具体以比值比（odds ratio, OR）呈现：以re1229984（ADH1B）基因型为基准，对比罕见等位基因（显性模型）携带者与常见等位基因纯合基因型携带者的上呼吸消化道癌比值比。上述比值比均经年龄、性别、研究中心、累计饮酒量以及相关吸烟状况进行标准化校正。比值比与95%置信区间（CI）均通过固定效应模型推导得出。本图表经自然出版集团（Nature Publishing Group）许可，改编自Hashibe等（2008年）发表的文献[57]。