Probabilities of source aberration with downstream target for lung cancer subtypes.

For smoking history based categories of lung cancer, the heatmap represents the probabilities that the indicated gene is a DNA-aberrant source gene with some downstream RNA-aberrant target. The sources are selected from the set of core genes for coverings of the given tissue; the selection criterion is that the probability of a DNA-aberration is high for at least one of the subtypes for that tissue. TP53 and KRAS are both more frequently DNA-aberrant (with some downstream RNA-aberrant target) among smokers than non-smokers whereas EGFR is a more aberrant source among non-smokers.