Probabilities of source aberration with downstream target for lung cancer subtypes.

For smoking history based categories of lung cancer, the heatmap represents the probabilities that the indicated gene is a DNA-aberrant source gene with some downstream RNA-aberrant target. The sources are selected from the set of core genes for coverings of the given tissue; the selection criterion is that the probability of a DNA-aberration is high for at least one of the subtypes for that tissue. TP53 and KRAS are both more frequently DNA-aberrant (with some downstream RNA-aberrant target) among smokers than non-smokers whereas EGFR is a more aberrant source among non-smokers.

针对基于吸烟史分组的肺癌类别，本热图呈现了指定基因作为DNA异常源基因（DNA-aberrant source gene）并携带下游RNA异常靶标的概率。上述源基因从覆盖目标组织的核心基因集中筛选得到，筛选标准为：针对该组织的至少一种亚型，其DNA异常（DNA-aberration）发生概率较高。其中，肿瘤蛋白p53（TP53）与Kirsten大鼠肉瘤病毒癌基因同源物（KRAS）在吸烟者中发生DNA异常（并伴随下游RNA异常靶标）的频率均高于非吸烟者；而表皮生长因子受体（EGFR）在非吸烟者中则为更易发生异常的源基因。