Comparative Analysis of Pseudomonas aeruginosa Isolates from Different Clinical Sources Using Whole Genome Sequencing and Bioinformatics.

Pseudomonas aeruginosa is a versatile opportunistic pathogen that poses a significant threat in healthcare settings. It is known to cause severe infections in immunocompromised individuals, particularly those with cystic fibrosis, burn wounds, and hospitalized patients. Understanding the genomic diversity and virulence factors of P. aeruginosa isolates from various clinical sources is crucial for developing effective therapeutic strategies. This proposal aims to investigate the comparative analysis of P. aeruginosa isolates using bioinformatics and whole genome sequencing techniques.

铜绿假单胞菌（Pseudomonas aeruginosa）是一种具有广泛适应性的机会致病菌，在医疗环境中构成显著的感染威胁。该菌可引发免疫功能低下人群的严重感染，尤以囊性纤维化患者、烧伤创面患者及住院患者为甚。解析不同临床来源的铜绿假单胞菌分离株的基因组多样性与毒力因子，对于开发高效治疗策略至关重要。本研究计划拟采用生物信息学与全基因组测序（whole genome sequencing）技术，开展铜绿假单胞菌分离株的比较分析研究。