Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment: Supplementary material

These files include source data and supplementary tables for the study titled “Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment (MCI)”. The aim of this study was to compare cerebrovascular and systemic vascular function between older adults with and without MCI, and to assess the strength of association between these outcomes. In 41 adults with MCI and 34 adults without MCI (control) we compared middle cerebral artery velocity (MCAv) and cerebrovascular pulsatility index (PI) at rest, cerebrovascular reactivity to CO2 using a breath-hold test, and responsiveness to changes in blood pressure during repeated stand-sit transitions (%∆MCAv/%∆MAP). Systemic vascular function was assessed by flow-mediated dilation (FMD) and aortic stiffness by pulse wave velocity (PWV).

本数据集包含题为《伴/不伴轻度认知障碍（mild cognitive impairment, MCI）老年人的脑血管功能及其与全身动脉功能和僵硬度的关联》的研究的源数据与补充表格。本研究旨在比较伴与不伴MCI的老年人的脑血管及全身血管功能，并评估上述指标间的关联强度。研究纳入41名MCI患者与34名无MCI的健康对照者，对两组受试者的以下指标进行了比较：静息状态下的大脑中动脉流速（middle cerebral artery velocity, MCAv）与脑血管搏动指数（pulsatility index, PI）、通过屏气试验检测的CO₂脑血管反应性，以及反复站坐动作期间血压变化对应的脑血管反应性（%ΔMCAv/%Δ平均动脉压（mean arterial pressure, MAP））。全身血管功能采用血流介导的舒张（flow-mediated dilation, FMD）进行评估，主动脉僵硬度则通过脉搏波速度（pulse wave velocity, PWV）进行检测。