Association of glutamate metabotropic receptor polymorphisms and sensorineural hearing loss in adults of different age groups

Abstract Introduction: Sensorineural hearing loss is a common challenge all over the world, including a section of the young population. While there have been many published reports associating glutamate metabotropic receptor 7 with sensorineural hearing loss, there is no report, till date, about the association of glutamate metabotropic receptor 7 polymorphisms with sensorineural hearing loss at different ages. Objective: To test the association between the single nucleotide polymorphisms rs11928865 and rs11920109 of the glutamate metabotropic receptor 7 with sensorineural hearing loss in adults of different age groups. Methods: A total of 1661 subjects were studied. The individuals aged between 30 and 50, and between 51 and 70 years with sensorineural hearing loss comprised group A and group B, respectively. Individuals aged between 30 and 50; and between 51 and 70 years without hearing loss comprised control groups C and D, respectively. The MassARRAY method was used to analyze the genotypes. Results: The difference in genotypes for the glutamate metabotropic receptor 7 rs11928865 single nucleotide polymorphism between patients in the groups B and D was statistically significant (p = 0.018). The distribution frequencies of genotypes in patients that were aged between 30 and 50 years were not significantly different. The difference in genotypes for the rs11920109 single nucleotide polymorphism between the sensorineural hearing loss groups and control groups showed no statistical significance. Conclusion: The rs11928865 single nucleotide polymorphism was associated with the susceptibility to hearing loss in patients in group B but not with those in group A.

研究背景：感音神经性听力损失是全球范围内的常见难题，且可累及部分青年人群。尽管已有诸多公开研究将谷氨酸代谢型受体7（glutamate metabotropic receptor 7）与感音神经性听力损失相关联，但截至目前，尚无关于谷氨酸代谢型受体7多态性与不同年龄段人群感音神经性听力损失相关性的研究报道。
研究目的：探讨谷氨酸代谢型受体7的单核苷酸多态性位点rs11928865与rs11920109与不同年龄段成人感音神经性听力损失的相关性。
研究方法：本研究共纳入1661名研究对象。其中，30~50岁、51~70岁的感音神经性听力损失患者分别纳入A组与B组；30~50岁、51~70岁的听力正常人群分别作为对照组C与对照组D。采用MassARRAY技术对研究对象的基因型进行检测分析。
研究结果：谷氨酸代谢型受体7 rs11928865单核苷酸多态性的基因型分布在B组与D组间差异具有统计学意义（p=0.018）；30~50岁人群的基因型分布频率无显著差异。rs11920109单核苷酸多态性的基因型分布在感音神经性听力损失组与对照组间均无统计学差异。
研究结论：rs11928865单核苷酸多态性与B组患者的听力损失易感性相关，但与A组患者无显著关联。