Spatially targeted inhibitory rhythms differentially affect neuronal integration

This dataset contains simulation output from a biophysical model of a cortical pyramidal neuron receiving excitatory Poisson input and inhibitory input that was either Poisson or rhythmically modulated. The simulations investigated how beta (16 Hz) and gamma (64 Hz) inhibitory rhythms targeted to different dendritic compartments (distal dendrites vs. perisomatic region) differentially affect dendritic spike generation and somatic action potential output.
Key findings:
- Beta (16 Hz) inhibition on distal dendrites strongly entrains Ca²⁺, NMDA, and Na⁺ dendritic spikes in a phase-dependent manner, with ~75% modulation depth.
- Gamma (64 Hz) inhibition on the perisomatic region minimally modulates dendritic spikes but modulates action potential generation by shifting the somatic voltage threshold via shunting.
- Excitation/inhibition balance effects differ by location: lagging perisomatic inhibition reduces firing, while lagging distal inhibition decreases firing up to 125 ms lag then reco..., , # Data from: Spatially targeted inhibitory rhythms differentially affect neuronal integration

https://doi.org/10.5061/dryad.v6wwpzhb8

See manuscript at Headley et al. (2026), \"Spatially targeted inhibitory rhythms differentially affect neuronal integration\", *eLife*.

## Overview

This dataset contains simulation output from a biophysical model of a cortical pyramidal neuron receiving excitatory Poisson input and inhibitory input that was either Poisson or rhythmically modulated. The simulations investigated how beta (16 Hz) and gamma (64 Hz) inhibitory rhythms targeted to different dendritic compartments (distal dendrites vs. perisomatic region) differentially affect dendritic spike generation and somatic action potential output.

Key findings:

* **Beta (16 Hz) inhibition on distal dendrites** strongly entrains Ca²⁺, NMDA, and Na⁺ dendritic spikes in a phase-dependent manner, with ~75% modulation depth.
* **Gamma (64 Hz) inhibition on the perisomatic region** minimally modulates den..., ,

本数据集包含皮层锥体神经元生物物理模型的仿真输出结果，该神经元接收兴奋性泊松（Poisson）输入，以及可采用泊松分布或节律调制形式的抑制性输入。本仿真实验探究了靶向不同树突区域（远端树突与胞体周围区域）的β（16 Hz）与γ（64 Hz）节律性抑制输入，如何差异性影响树突尖峰产生与体细胞动作电位输出。

### 核心发现
- 靶向远端树突的β（16 Hz）抑制输入以相位依赖方式显著同步调控钙（Ca²⁺）、NMDA及钠（Na⁺）树突尖峰，调制深度约为75%。
- 靶向胞体周围区域的γ（64 Hz）抑制输入对树突尖峰的调制作用极弱，但可通过分流效应改变体细胞电压阈值，进而调控动作电位的产生。
- 兴奋-抑制平衡的效应因作用位置而异：滞后的胞体周围抑制会降低神经元放电频率，而滞后的远端树突抑制可使放电频率降低长达125 ms，随后恢复……

# 数据来源：Spatially targeted inhibitory rhythms differentially affect neuronal integration
https://doi.org/10.5061/dryad.v6wwpzhb8

详见Headley等人（2026）发表于*eLife*的论文《靶向空间分布的抑制性节律差异性调控神经元整合功能》。

## 概述
本数据集包含皮层锥体神经元生物物理模型的仿真输出结果，该神经元接收兴奋性泊松输入，以及可采用泊松分布或节律调制形式的抑制性输入。本仿真实验探究了靶向不同树突区域（远端树突与胞体周围区域）的β（16 Hz）与γ（64 Hz）节律性抑制输入，如何差异性影响树突尖峰产生与体细胞动作电位输出。

### 核心发现
- **靶向远端树突的β（16 Hz）抑制输入**以相位依赖方式显著同步调控钙（Ca²⁺）、NMDA及钠（Na⁺）树突尖峰，调制深度约为75%。
- **靶向胞体周围区域的γ（64 Hz）抑制输入**对树突尖峰的调制作用极弱……