Variation analysis of SARS-CoV-2 complete sequences from Iran: Supplementary data

Aim: SARS-CoV-2 is an emerging coronavirus that was discovered in China and rapidly spread throughout

the world. The authors looked at nucleotide and amino acid variations in SARS-CoV-2 genomes, as well

as phylogenetic and evolutionary events in viral genomes, in Iran. Materials & methods: All SARS-CoV-

2 sequences that were publicly released between the start of the pandemic and 15 October 2021 were

included. Results: Themajority of mutations were found in vaccine target proteins, Spike and Nucleocapsid

proteins, and nonstructural proteins. The majority of the viruses that circulated in the early stages of the

pandemic belonged to the B.4 lineage. Conclusion: We discovered the prevalence of viral populations

in Iran. As a result, tracking the virus’s variation in Iran and comparing it with a variety of nearby

neighborhoods may reveal a pattern for future variant introductions.

研究目的：严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）是一种于中国被发现的新型冠状病毒，随后迅速在全球范围内传播。本研究聚焦伊朗境内的SARS-CoV-2基因组，对其核苷酸与氨基酸变异情况，以及病毒基因组的系统发育与进化事件展开分析。材料与方法：纳入新冠疫情暴发初期至2021年10月15日期间公开发布的全部SARS-CoV-2序列。结果：绝大多数突变分布于疫苗靶标蛋白刺突蛋白（Spike）、核衣壳蛋白（Nucleocapsid）以及非结构蛋白中。疫情早期流行的病毒株绝大多数属于B.4进化分支。结论：本研究明确了伊朗境内病毒种群的流行态势。据此，对伊朗境内的病毒变异情况进行追踪，并与周边多个区域开展对比分析，或可为未来病毒变异株的引入模式提供参考依据。