Cyclodextrin/PVP-based nanofibers with Rhadiola rosea extract as a new concept for increasing bioavailability of active components

Dissolution_rosarin.xlsx - data represent the percentage of rosarin released. Columns indicate the systems tested, rows the corresponding time points. Data are presented as a percentage. Dissolution studies of electrospun nanofibers were performed using an Agilent 708-DS dissolution apparatus. A standard basket method was used at 37 ± 0.5 °C with a stirring speed of 50 rpm. Nanofibers were placed in 30 mL of artificial saliva solution at pH 6.8 (potassium chloride (1.20 g), sodium chloride (0.85 g), di-potassium hydrogen orthophosphate (0.35 g), magnesium chloride (0.05 g), calcium chloride (0.20 g), xylitol (20.0 g) and water up to 1 L; pH was adjusted to 6.8 by 1 M HCl). The liquid samples were collected at specified time intervals, and an equal volume of temperature-equilibrated media was replaced. The samples were filtered through a 0.45 μm nylon membrane filter. The concentration was determined using the HPLC method (https://www.mdpi.com/1420-3049/30/16/3359) and converted, relative to the weight, into the percentage of the substance released during the experiment.Dissolution_salidroside.xlsx - data represent the percentage of salidroside released. Columns indicate the systems tested, rows the corresponding time points. Data are presented as a percentage. Dissolution studies of electrospun nanofibers were performed using an Agilent 708-DS dissolution apparatus. A standard basket method was used at 37 ± 0.5 °C with a stirring speed of 50 rpm. Nanofibers were placed in 30 mL of artificial saliva solution at pH 6.8 (potassium chloride (1.20 g), sodium chloride (0.85 g), di-potassium hydrogen orthophosphate (0.35 g), magnesium chloride (0.05 g), calcium chloride (0.20 g), xylitol (20.0 g) and water up to 1 L; pH was adjusted to 6.8 by 1 M HCl). The liquid samples were collected at specified time intervals, and an equal volume of temperature-equilibrated media was replaced. The samples were filtered through a 0.45 μm nylon membrane filter. The concentration was determined using the HPLC method (https://www.mdpi.com/1420-3049/30/16/3359) and converted, relative to the weight, into the percentage of the substance released during the experiment.

Dissolution_rosarin.xlsx - 数据为蔷薇苷（rosarin）的释放百分比。列代表所测试的体系，行代表对应的时间点，所有数据以百分比形式呈现。电纺纳米纤维的溶出实验采用安捷伦（Agilent）708-DS溶出度仪完成，实验采用标准篮法，温度设置为37±0.5℃，搅拌转速为50 rpm。将纳米纤维置于30 mL pH 6.8的人工唾液溶液中（该溶液配方为：氯化钾1.20 g、氯化钠0.85 g、磷酸氢二钾0.35 g、氯化镁0.05 g、氯化钙0.20 g、木糖醇20.0 g，加水定容至1 L；使用1 M HCl将pH调至6.8）。按指定时间间隔采集液体样品，并补充等体积的恒温介质。样品经0.45 μm尼龙微孔滤膜过滤后，采用高效液相色谱法（HPLC）进行浓度测定（参考方法来源：https://www.mdpi.com/1420-3049/30/16/3359），最终将测定结果以相对于样品总重量的百分比形式表示，即实验过程中释放的物质占比。Dissolution_salidroside.xlsx - 数据为红景天苷（salidroside）的释放百分比。列代表所测试的体系，行代表对应的时间点，所有数据以百分比形式呈现。电纺纳米纤维的溶出实验采用安捷伦（Agilent）708-DS溶出度仪完成，实验采用标准篮法，温度设置为37±0.5℃，搅拌转速为50 rpm。将纳米纤维置于30 mL pH 6.8的人工唾液溶液中（该溶液配方为：氯化钾1.20 g、氯化钠0.85 g、磷酸氢二钾0.35 g、氯化镁0.05 g、氯化钙0.20 g、木糖醇20.0 g，加水定容至1 L；使用1 M HCl将pH调至6.8）。按指定时间间隔采集液体样品，并补充等体积的恒温介质。样品经0.45 μm尼龙微孔滤膜过滤后，采用高效液相色谱法（HPLC）进行浓度测定（参考方法来源：https://www.mdpi.com/1420-3049/30/16/3359），最终将测定结果以相对于样品总重量的百分比形式表示，即实验过程中释放的物质占比。