DataSheet3_Nano-Sonosensitized Sonodynamic Nanomedicine Augments Tumor-Selective Catalytic Tumor Eradication.ZIP

Inspired by the distinct metabolic pathway of tumor cells, here a new anti-cancer therapy (i.e., Cu-TCPP(Fe) metal-organic frameworks (MOFs) with sonosensitizer for sonodynamic therapy (SDT) and tumor microenvironment (TME)-specific release of copper/iron for chemical catalysis) is introduced and verified. Upon exposure to ultrasound, the porphyrin structure in the MOFs yields reactive oxygen species (ROS), and the copper/iron induces the Fenton reaction in the TME existing H2O2 and acid. Thus, highly toxic ROS are generated through these TME-specific reactions to trigger the apoptosis and death of tumor cells. The current work paves a new avenue to design SDT with catalytic nanomedicine for the selective and effective treatment of tumors.

受肿瘤细胞独特代谢通路的启发，本研究提出并验证了一种新型抗癌疗法：即搭载声敏剂的Cu-TCPP(Fe)金属有机框架（metal-organic frameworks, MOFs），可用于声动力疗法（sonodynamic therapy, SDT），并能在肿瘤微环境（tumor microenvironment, TME）中特异性释放铜/铁以介导化学催化。当接受超声辐照时，该金属有机框架中的卟啉结构会产生活性氧簇（reactive oxygen species, ROS）；而释放出的铜/铁可依托肿瘤微环境中固有存在的过氧化氢与酸性环境触发芬顿反应（Fenton reaction）。借此，通过上述肿瘤微环境特异性反应生成的高毒性活性氧簇，可诱导肿瘤细胞凋亡并最终死亡。本研究为设计兼具声动力疗法与催化功能的纳米抗肿瘤药物，实现肿瘤的选择性高效治疗开辟了全新路径。