The PPI datasets,GO dataset, subcellular localization information and essential protein dataset

The PPI datasets were collected from four different sources: DIP, MIPS, Gavin, and Krogan. All self-interactions and repeated interactions were filtered. The essential proteins were collected from the following four different databases: MIPS,SGD,DEGand SGDP (http://www.sequence.stanford.edu/group/). Gene expression data were downloaded from the Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo/) with accession number GSE3431. The dataset includes three metabolism cycles with a total of 36 time points. The gene expression data set includes 9336 genes. The GO data applied in our method are extracted from the GO Consortium.The subcellular localization information is obtained from the COMPARTMENTS database.

蛋白质-蛋白质相互作用（Protein-Protein Interaction, PPI）数据集采集自四个不同的数据源：DIP、MIPS、Gavin及Krogan。所有自身相互作用与重复相互作用均已被过滤剔除。必需蛋白质数据集采集自以下四个数据库：MIPS、SGD、DEG及SGDP（http://www.sequence.stanford.edu/group/）。基因表达数据从基因表达综合数据库（Gene Expression Omnibus, GEO）下载获取，其登录号为GSE3431（http://www.ncbi.nlm.nih.gov/geo/）。本数据集包含3个代谢循环，共计36个时间点。该基因表达数据集共涵盖9336个基因。本研究方法中所使用的基因本体（Gene Ontology, GO）数据提取自基因本体联合会（GO Consortium）。亚细胞定位信息源自COMPARTMENTS数据库。