HCA Gonads Foetal EU H2020 HUGODECA RNA

Cell Atlas of human fetal gonads

The HUGODECA consortium brings together leading European academic and industrial experts (from 5 different EU countries). It includes active contributors and executives of the Human Cell Atlas (HCA) which will ensure complementarity with other ongoing HCA efforts. The overall HUGODECA concept is grounded on the integration of multiple synergistic expertise and technologies: Single cell profiling, spatial transcriptomic, 2D Mass cytometry and cyclic immunofluorescence and 3D imaging of optically cleared gonads. HUGODECA will implement novel tools, analytical and computational methods to process and integrate multidimensional OMICS and image data across different platforms. It will evaluate the accuracy of ex vivo culture models of human gonadal development and assess consequences of altering key signalling pathways.

This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/EGA study EGAS00001004723

人类胎儿性腺细胞图谱

HUGODECA联盟汇聚了来自5个欧盟成员国的顶尖欧洲学术与工业领域专家。该联盟吸纳了人类细胞图谱（Human Cell Atlas，HCA）的核心参与者与管理人员，可确保与其他正在推进的HCA项目形成互补。HUGODECA的整体理念立足于多类协同专业技术与研究方法的整合，涵盖单细胞分析（Single cell profiling）、空间转录组学（spatial transcriptomics）、二维质谱流式细胞术（2D Mass cytometry）、环状免疫荧光，以及经光学透明化处理的性腺三维成像。HUGODECA将开发新型工具、分析与计算方法，用于处理并整合多平台的多维度组学（OMICS）与影像数据。该联盟还将评估人类性腺发育体外（ex vivo）培养模型的准确性，并解析关键信号通路改变所带来的影响。

本数据集属于预发布数据。若需了解惠康桑格研究所（Wellcome Trust Sanger Institute）共享的预发布数据的规范使用方式（包括各类出版暂缓政策细节），请访问 http://www.sanger.ac.uk/datasharing/ 查看EGA研究项目EGAS00001004723的相关说明。