Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement

ABSTRACT Purpose: To analyze the clinical outcomes of the ocular surface in patients with vitamin D deficiency after oral replacement. Methods: A total of 40 patients with vitamin D deficiency were enrolled in the study. The patients received 50,000 units of oral vitamin D weekly over a period of 8 weeks. After 8 weeks, 1,500-2,000 units/d were administered for 24 weeks. Eyelid margin score, meibomian gland expressibility score, Oxford grading, Schirmer I test, tear breakup time, tear osmolarity, and the Ocular Surface Disease Index score were evaluated at baseline, and at 8, 12, and 24 weeks. Results: The meibomian gland expressibility score, Schirmer I, tear breakup time, tear osmolarity, and Ocular Surface Disease Index score showed improvement 8 weeks after vitamin D supplementation (p

摘要
研究目的：分析维生素D缺乏患者经口服维生素D替代治疗后的眼表临床结局。
研究方法：本研究共纳入40例维生素D缺乏患者。受试者每周接受50000单位口服维生素D补充，疗程为8周；8周后改为每日1500~2000单位，持续治疗24周。分别于基线期、第8、12及24周评估睑缘评分（eyelid margin score）、睑板腺可压出性评分（meibomian gland expressibility score）、牛津分级（Oxford grading）、施墨I试验（Schirmer I test）、泪膜破裂时间（tear breakup time）、泪液渗透压（tear osmolarity）及眼表疾病指数（Ocular Surface Disease Index, OSDI）评分。
研究结果：维生素D补充8周后，受试者的睑板腺可压出性评分、施墨I试验结果、泪膜破裂时间、泪液渗透压及眼表疾病指数评分均得到改善（p