Epitheliotropic lymphoma with heart and kidney metastasis in a dog: case report

ABSTRACT A female adult dog, with a four-month history of pain and intense pruritus, which eventually resulted in sudden death, was referred for necropsy. Postmortem examination showed thoracic and abdominal serum-sanguineous exudates, multifocal infiltrative renal masses, and similar tumors in the heart. Histopathology revealed midsize infiltrative neoplastic proliferation composed of round cells, sparse cytoplasm, and large hyperchromatic nuclei. Immunohistochemistry revealed CD3+ and CD20-immunoexpression. Histopathological and immunohistochemical findings confirmed the diagnosis of epitheliotropic lymphoma with cardiac and renal metastasis.

摘要：本研究对一只成年母犬进行尸检，该犬有4个月的疼痛与剧烈瘙痒病史，最终突发死亡。尸检可见胸腔与腹腔内存在浆液血性渗出物，肾脏出现多灶性浸润性肿块，心脏内也存在同类肿瘤。组织病理学检查显示，病灶为中等大小的浸润性肿瘤性增生，由圆形细胞构成，胞质稀少，细胞核大且深染。免疫组织化学检测显示，肿瘤细胞呈CD3阳性、CD20阴性表达。结合组织病理学与免疫组织化学检测结果，确诊该犬患有亲上皮性淋巴瘤，并已发生心脏与肾脏转移。