Text S1 - Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans

Supporting information. Includes: Figure S1. Validation of 16S rDNA Gene to Normalize Leptospira In Vivo Gene Expression. Figure S2. Alignment of Bartonella bacilliformis and Leptospira interrogans serovar Lai anonymous paralog families. Table S1. Leptospira Species Distribution of Pathogenomically-Discovered Genes. Table S2. Differential Expression of Gene Family Members During Exposure of L. interrogans to Host-like Conditions. Table S3. Primers used for In-vivo RT-qPCR Analysis. Table S4. Genome locus tags and GenBank protein sequence accession numbers for Bartonella bacilliformis and Helicobacter spp. PF07598 family homologs used to construct Figure 5A. (DOCX)补充信息。包含如下内容：图S1：用于标准化钩端螺旋体（Leptospira）体内基因表达的16S rDNA基因验证实验；图S2：杆状巴尔通体（Bartonella bacilliformis）与问号钩端螺旋体赖株（Leptospira interrogans serovar Lai）的未知旁系同源家族序列比对；表S1：经病原基因组学鉴定发现的基因在钩端螺旋体物种中的分布情况；表S2：问号钩端螺旋体（L. interrogans）暴露于宿主模拟环境时其基因家族成员的差异表达情况；表S3：体内逆转录实时定量聚合酶链反应（RT-qPCR）分析所用引物；表S4：用于构建图5A的杆状巴尔通体与螺杆菌属（Helicobacter spp.）PF07598家族同源蛋白的基因组基因座标签及GenBank蛋白序列登录号。（DOCX格式）