Visible-Light-Catalyzed [3 + 1 + 2] Coupling Annulations for the Synthesis of Unsymmetrical Trisubstituted Amino-1,3,5-triazines

A visible-light catalyzed [3 + 1 + 2] annulation for
the synthesis
of unsymmetrical trisubstituted amino-1,3,5-triazines from amidines,
isothiocyanates, and 1,1,3,3-tetramethylguanidines has been developed.
This method exhibits the advantages of easily available starting materials,
insensitive to air and moisture, wide substrate scopes, high step
economy, mild, metal- and ligand-free conditions, which has potential
applications in the organic, medicinal, and material chemistry.

本研究开发了一种可见光催化的[3+1+2]环化反应，可通过脒、异硫氰酸酯与1,1,3,3-四甲基胍三种原料合成不对称三取代氨基-1,3,5-三嗪。该方法具备原料易得、对空气与湿气不敏感、底物适用范围广泛、步骤经济性高、反应条件温和且无需金属与配体等优势，在有机化学、药物化学及材料化学领域具有潜在应用价值。