Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

RATIONALE: Hepatic arterial infusion uses a catheter to carry tumor-killing substances directly into the liver. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving floxuridine and dexamethasone directly into the arteries around the tumor together with combination chemotherapy may kill more tumor cells.
PURPOSE: This phase II trial is studying how well hepatic arterial infusion with floxuridine and dexamethasone works when given together with combination chemotherapy in treating patients with colorectal cancer that has spread to the liver.

原理：肝动脉灌注（hepatic arterial infusion）是通过导管将抗肿瘤物质直接输送至肝脏的治疗手段。化疗药物可通过多种机制抑制肿瘤细胞增殖，既可直接杀伤肿瘤细胞，亦可阻断其分裂过程。在联合化疗的基础上，将氟尿苷（floxuridine）与地塞米松（dexamethasone）直接注入肿瘤周围动脉，或可更高效地杀伤肿瘤细胞。
试验目的：本项II期临床试验旨在评估氟尿苷与地塞米松肝动脉灌注联合联合化疗方案，治疗已发生肝转移的结直肠癌患者的临床疗效。