Serum neutralizing antibody response induced by a single 103 PFU dose of rDEN1Δ30.

1Plaque reduction neutralization titer 60%. Geometric mean titers calculated for all subjects who developed detectable antibody, including those who did not seroconvert (see footnote 3).2Infection is defined as recovery of vaccine virus from the blood and/or seroconversion to DEN1.3Seroconversion is defined as a ≥4-fold rise in PRNT60 at day 28 or 42 post-vaccination.4Previous trial. All serum samples from the current and previous trial were re-assayed concurrently.

1. 60%噬斑减少中和效价（Plaque reduction neutralization titer 60%，PRNT60）：针对所有产生可检测抗体的受试者（包括未发生血清阳转的受试者，详见脚注3）计算几何平均滴度。
2. 感染定义为从血液中分离得到疫苗病毒，或针对登革病毒1型（DEN1）发生血清阳转。
3. 血清阳转定义为疫苗接种后第28天或第42天的PRNT60效价升高≥4倍。
4. 既往临床试验：本次及既往临床试验的所有血清样本均同步进行了重新检测。