mQTLs_with_differential_methylation_in_CCC_and_asymptomatics.tsv

Significant methylation quantitative trait loci (mQTL) in the associated region that also produce significant (p-value<0.05) methylation changes among chronic Chagas cardiomyopathy patients and asymtomatic individuals. This file has five columns: CpG_ID (identificator for each DNA methylation site), SNP_CHR:POSITION (chromosomic position of the single nucleotide polymorphism), Differential_Methylation_Pvalue (p-value of the differentail methylation among chronic Chagas cardiomyopathy patients and asymptomatic individuals), PVALUE (p-value of the integration test of the genomic and methylation data), FDR (integration False Discovery Rate), BETA (effect of the mQTL under study), SE (integration standard error), R2 (SNP-DNA site correlation value).

本数据集涵盖关联区域内的显著甲基化数量性状位点（methylation quantitative trait loci, mQTL），此类位点可在慢性恰加斯心肌病患者与无症状个体间引发具有统计学显著性的甲基化变化（P值<0.05）。本文件包含以下列项：CpG_ID（每个DNA甲基化位点的标识符）、SNP_CHR:POSITION（单核苷酸多态性的染色体位置）、Differential_Methylation_Pvalue（慢性恰加斯心肌病患者与无症状个体间的差异甲基化P值）、PVALUE（基因组与甲基化数据整合检验的P值）、FDR（整合检验错误发现率）、BETA（当前研究中mQTL的效应值）、SE（整合检验标准误）、R2（单核苷酸多态性与DNA位点的相关系数）。