The Netherlands BAG

The Netherlands BAG includes structural biology and enzymology groups situated at six Dutch universities (Utrecht, Groningen, Wageningen, Leiden, Eindhoven and Maastricht) and at the Netherlands Cancer Institute in Amsterdam, with a total of fourteen PIs. While the structural biology research projects carried out in these groups are highly diverse, they can be largely classified into two major themes: (i) research on proteins and systems with a strong biomedical relevance and (ii) research concerning the design of new biocatalysts for green chemistry and new-to-nature reactions. Projects deal with prokaryotic and eukaryotic proteins, membrane and soluble proteins, cell surface receptors, and protein-protein, protein-ribonucleotide, protein-drug and enzyme-ligand complexes.荷兰BAG数据集（Netherlands BAG）包含了隶属于荷兰6所大学（乌得勒支、格罗宁根、瓦赫宁根、莱顿、埃因霍芬、马斯特里赫特）以及阿姆斯特丹荷兰癌症研究所的结构生物学与酶学研究团队，共计14名首席研究员（Principal Investigators，PIs）。上述团队开展的结构生物学研究项目高度多元，大致可划分为两大核心主题：(i) 具备强生物医学相关性的蛋白质及相关系统研究；(ii) 面向绿色化学与全新非天然反应的新型生物催化剂设计研究。项目研究对象涵盖原核与真核生物蛋白质、膜蛋白与可溶性蛋白、细胞表面受体，以及蛋白质-蛋白质、蛋白质-核糖核苷酸、蛋白质-药物与酶-配体复合物。