Pulmonary adenocarcinoma in a captive ocelot (Leopardus pardalis): morphologic and immunophenotypic characterization - case report

ABSTRACT Pulmonary adenocarcinoma is a malignant epithelial neoplasia that usually arises from conducting airways or alveolar parenchyma. It has rarely been described in wild felids, with no previous reports in ocelots. In domestic cats it is a very aggressive neoplasm with a high metastatic rate that usually evolves to death. This report aimed to describe a pulmonary adenocarcinoma in a captive and senile ocelot (Leopardus pardalis), with a thorough morphologic and immunophenotypically characterization, evidencing the epithelial-mesenchymal transition (EMT) phenomenon in a high metastatic carcinoma, an important feature rarely described in veterinary medicine, even in domestic cats.

摘要：肺腺癌（pulmonary adenocarcinoma）是一类通常起源于传导气道或肺泡实质的恶性上皮性肿瘤。该疾病在野生猫科动物中鲜有报道，目前尚无虎猫（Leopardus pardalis）相关病例的既往研究记录。在家猫中，肺腺癌属于侵袭性极强的肿瘤，转移率极高，多数病例病情进展最终导致死亡。本报告旨在描述一例圈养老年虎猫的肺腺癌病例，并对其开展全面的形态学与免疫表型特征分析，证实该高转移性癌存在上皮间质转化（epithelial-mesenchymal transition, EMT）现象——这一重要特征在兽医学领域（即便在家猫病例中）均鲜有报道。