Key elements of Apaf-1 and NLR NACHT-WH-SH domains extracted from the multiple sequence alignment in Figure 1.

Sequence identities shown are derived from pairwise alignments using FFAS between Apaf-1 and individual NLRs. WH His and WH cons show the conserved histidine and the conserved METEEV sequence patch, respectively which are located in the winged helix (WH) domain.

本研究展示的序列同一性，通过FFAS工具对凋亡蛋白酶激活因子1（Apaf-1）与各单个核苷酸结合寡聚化结构域样受体（NLRs）进行双序列比对得到。WH His与WH_cons分别代表位于翼螺旋（WH）结构域内的保守组氨酸与保守METEEV序列基序。