PET and the multitracer concept in the study of neurodegenerative diseases

ABSTRACT The complexity of the pathological reactions of the brain to an aggression caused by an internal or external noxa represents a challenge for molecular imaging. Positron emission tomography (PET) can indicate in vivo,anatomopathological changes involved in the development of different clinical symptoms in patients with neurodegenerative disorders. PET and the multitracer concept can provide information from different systems in the brain tissue building an image of the whole disease. We present here the combination of 18F-flourodeoxyglucose (FDG) and N-[11C-methyl]-L-deuterodeprenyl (DED), FDG and N-[11C-methyl] 2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (PIB), PIB and L-[11C]-3'4-Dihydrophenylalanine (DOPA) and finally PIB and [15O]H2O.

摘要：内外源性致病因子诱发脑损伤后所产生的病理反应，其复杂性为分子影像学研究带来了挑战。正电子发射断层扫描（Positron Emission Tomography, PET）可在活体状态下，反映神经退行性疾病患者出现不同临床症状过程中所涉及的病理解剖改变。正电子发射断层扫描技术与多示踪剂理念相结合，能够从脑组织的多个系统获取信息，构建反映整体疾病进程的影像图谱。本文在此介绍了以下几组示踪剂组合方案：18F-氟代脱氧葡萄糖（18F-fluorodeoxyglucose, FDG）与N-[11C-甲基]-L-氘代丙炔苯丙胺（DED）、FDG与N-[11C-甲基]-2-(4'-甲氨基苯基)-6-羟基苯并噻唑（PIB）、PIB与L-[11C]-3',4'-二羟基苯丙氨酸（DOPA），以及PIB与[15O]标记水（[15O]H₂O）。