Effects of eicosapentaneoic acid on innate immune responses in Atlantic salmon kidney cells in vitro

Cellular immunity against viruses is based on detection of viral components like dsRNA which is formed during viral replication. Activation of receptors for these molecules leads to signalling events resulting in production of cytokines like interferon and antiviral proteins. We have investigated how various levels of the n-3 unsaturated fatty acid eicosapentaenoic acid influence these processes in cells from Atlantic salmon stimulated with a synthetic ds RNA molecule; poly I:C or infected with viruses like ISAV and SAV3.

抗病毒细胞免疫的核心在于识别病毒复制过程中产生的病毒组分，例如双链RNA（double-stranded RNA, dsRNA）。此类分子的受体被激活后，会触发一系列信号转导事件，最终促使细胞产生干扰素等细胞因子及抗病毒蛋白。本研究探究了不同浓度的n-3不饱和脂肪酸二十碳五烯酸（eicosapentaenoic acid）对经合成双链RNA分子聚肌胞苷酸（poly I:C）刺激或感染ISAV、SAV3的大西洋鲑细胞中上述免疫过程的影响。