Martinez_pacheco, et al., Original Data

This study aimed to evaluate the effect of two inhibitors of class I histone deacetylases (HDACs), 4-phenylbutyrate (PB) and IN14, on memory performance in mice exposed to a single forced swimming stress session. The database shows the results of the manuscript: "CLASS I HISTONE DEACETYLASES INHIBITION REVERSES MEMORY IMPAIRMENT INDUCED BY ACUTE STRESS IN MICE". <br> 1. Corticosterone levels of each experimental group: VEH (vehicle), PB, and IN14 (stress and not stress). 2. Motor activity: results are shown as the number of counts in 5 min of total, ambulatory, and vertical activity. 3. Novel Object Recognition Test (NORT): results are shown as the discrimination index (1h and 24 h) of each experimental group (VEH, PB, IN14 (stress and not stress). 4. Elevated T maze (ETM): results are shown as the acquisition latency, "AL" ( AL1, AL2, AL3, and AL4) which is considered the learning criterion. LR indicates the retention latency (the time to leave the enclosed arm "seconds"), and EL indicates the escape latency (time to enter with all four paws to the enclosed arm "seconds"). 5. Buried food location test (BFLT). results are shown as the acquisition latency, "AL" ( AL1, AL2, AL3, AL4, AL5, and AL6) that is the time finding the pellet, LR indicates the retention latency, "T/O" is the time in the target quadrant and opposite respectively (seconds). 6. HDAC2: expression of HDAC2 in the mouse hippocampus (OD/ml).

本研究旨在评估I类组蛋白去乙酰化酶（histone deacetylases, HDACs）的两种抑制剂——4-苯基丁酸（4-phenylbutyrate, PB）与IN14，对经历单次强迫游泳应激的小鼠记忆表现的影响。本数据集包含手稿"CLASS I HISTONE DEACETYLASES INHIBITION REVERSES MEMORY IMPAIRMENT INDUCED BY ACUTE STRESS IN MICE"的相关实验结果。<br>1. 各实验组的皮质酮水平：涵盖溶剂对照（vehicle, VEH）组、PB组及IN14组（含应激与非应激亚组）。<br>2. 运动活动指标：结果以5分钟内总活动、移动活动及直立活动的计数总数进行表征。<br>3. 新物体识别实验（Novel Object Recognition Test, NORT）：结果以各实验组（VEH、PB、IN14，含应激与非应激亚组）在1小时与24小时时间点的辨别指数呈现。<br>4. 高架T迷宫（Elevated T maze, ETM）：结果以获得潜伏期（acquisition latency, AL）表示，包含AL1、AL2、AL3及AL4，该指标被视作学习能力的评判标准。LR代表保留潜伏期，即小鼠离开封闭臂的时长（单位：秒）；EL代表逃避潜伏期，即小鼠四肢全部进入封闭臂的时长（单位：秒）。<br>5. 埋藏食物位置实验（Buried Food Location Test, BFLT）：结果以获得潜伏期"AL"（包含AL1、AL2、AL3、AL4、AL5及AL6）表示，该指标为小鼠找到食物颗粒的耗时；LR代表保留潜伏期，"T/O"分别指代目标象限与对侧象限的停留时长（单位：秒）。<br>6. 组蛋白去乙酰化酶2（HDAC2）：小鼠海马组织中HDAC2的表达水平（单位：光密度/毫升，OD/ml）。