The role of DNMT3A in AITL

To investigate the role of DNMT3A in AITL, single cell RNA-seq (scRNA-seq) is performed to analysis the lymph nodes generated from the control, RHOAG17V and RHOAG17V DNMT3AR882H AITL mice. The mitoQC maps shows the distributions of unique gene detected and mitochondrial genes detected in each single cell. After the quality control, a total of 23,805 cells (7576 of control, 7913 of RHOAG17V and 8316 of RHOAG17V DNMT3AR882H) are used for clustering and further analyzing Overall design: single-cell RNA-seq This record includes re-analysis of all samples in GSE197188. Data processing description and re-analyzed data (GSE218137_AITL_patient.rds.gz) are available for download at the foot of this record.

为探究DNA甲基转移酶3A（DNMT3A）在血管免疫母细胞性T细胞淋巴瘤（AITL）中的作用，本研究对对照组、RHOAG17V模型组及RHOAG17V DNMT3AR882H双突变模型组AITL小鼠的淋巴结样本开展了单细胞RNA测序（scRNA-seq）分析。mitoQC图谱展示了各单细胞中检测到的独特基因与线粒体基因的分布情况。经质量控制后，共计23805个细胞（对照组7576个、RHOAG17V组7913个、RHOAG17V DNMT3AR882H组8316个）用于后续聚类分析与深入研究。总体实验设计：单细胞RNA测序。本记录包含对GSE197188中所有样本的重新分析。数据处理说明与重新分析得到的数据（GSE218137_AITL_patient.rds.gz）可在本记录页面底部下载。