Oxidation Reactivity Channels for 2-(Pyridin-2-yl)-<i>N</i>,<i>N</i>-diphenylacetamides

Synthetic routes to 2-(pyridin-2-yl)-N,N-diphenylacetamide and 2-(6-methylpyridin-2-yl)-N,N-diphenyl-acetamide are described along with results from the chemical oxidation of these compounds with peracetic acid, m-chloroperbenzoic acid, and OXONE. In each case, oxidations generate four products in varying amounts depending on the oxidant and reaction conditions. Each product has been characterized by spectroscopic methods and the molecular structures of several of the new compounds have been confirmed by X-ray crystallography.本文报道了2-(2-吡啶基)-N,N-二苯基乙酰胺（2-(pyridin-2-yl)-N,N-diphenylacetamide）与2-(6-甲基-2-吡啶基)-N,N-二苯基乙酰胺（2-(6-methylpyridin-2-yl)-N,N-diphenylacetamide）的合成路线，以及这两种化合物分别与过乙酸（peracetic acid）、间氯过氧苯甲酸（m-chloroperbenzoic acid）和OXONE进行化学氧化的实验结果。所有氧化反应均会生成四种产物，产物的相对含量随氧化剂种类与反应条件的不同而发生变化。所有产物均通过光谱学手段完成表征，其中多款新型化合物的分子结构已通过X射线晶体学（X-ray crystallography）方法得以确证。