Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex

The dataset includes spike times for recorded grid cells from the medial entorhinal cortex (MEC) in rats that explored two-dimensional environments. The behavioral data includes position from the tracking LEDs.

This sample was published in Sargolini et al. (Science, 2006).

Grid cells in the medial entorhinal cortex (MEC) are part of an environment-independent spatial coordinate system. To determine how information about location, direction, and distance is integrated in the grid-cell network, we recorded from each principal cell layer of MEC in rats that explored two-dimensional environments. Whereas layer II was predominated by grid cells, grid cells colocalized with head-direction cells and conjunctive grid x head-direction cells in the deeper layers. All cell types were modulated by running speed. The conjunction of positional, directional, and translational information in a single MEC cell type may enable grid coordinates to be updated during self-motion-based navigation.

本数据集包含大鼠在内嗅皮层内侧区（medial entorhinal cortex, MEC）记录得到的网格细胞（grid cells）放电时序数据，实验中大鼠于二维环境中完成探索行为。其配套行为学数据包含通过追踪LED采集的动物位置信息。
该数据集样本已发表于Sargolini等人2006年发表于《Science》的研究中。
内嗅皮层内侧区的网格细胞属于环境非依赖型空间坐标系统的组成部分。为探究位置、方向与距离信息在网格细胞网络中的整合机制，我们在大鼠探索二维环境时，对内嗅皮层内侧区的各主细胞层开展了单细胞记录。研究结果显示，II层以网格细胞为主；而在更深的细胞层中，网格细胞与头部方向细胞（head-direction cells）以及兼具网格与头部方向特性的联合细胞共存。所有细胞类型的活动均受奔跑速度的调控。单一内嗅皮层内侧区细胞类型同时携带位置、方向与平移信息，这一特性或可支持基于自身运动的导航过程中网格坐标的更新。