Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts.

<strong>ABSTRACT </strong> It contains the data of drug targets (gene names), uniprot identifiers, secondary linked data sources (e.g., PharmGKB), market drug name, chembl identifier, and pubchem compound identifier obtained from DGIdb. <strong>Instructions: </strong> Data were cleaned and duplicates were removed. Data were all categorical features. <strong>Inspiration:</strong> This dataset uploaded to U-BRITE for "DRG_DEPOT" summer 2023 team project. It is used for constructing R2G dataset, which will map drugs to their drug targets (gene -&gt; protein = drug target) <strong>Acknowledgements</strong> Freshour SL, Kiwala S, Cotto KC, Coffman AC, McMichael JF, Song JJ, Griffith M, Griffith OL, Wagner AH. Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res. 2021 Jan 8;49(D1):D1144-D1151. doi: 10.1093/nar/gkaa1084. PMID: 33237278; PMCID: PMC7778926. https://www.dgidb.org/ <strong>U-BRITE last update date:</strong> 06/09/2023<strong>摘要</strong> 本数据集包含从药物-基因相互作用数据库（DGIdb）获取的药物靶点（即基因名称，drug targets）、UniProt 标识符（UniProt）、二级关联数据源（例如PharmGKB数据库（PharmGKB））、上市药物名称、ChEMBL 标识符（ChEMBL）以及PubChem 化合物标识符（PubChem）相关数据。 <strong>数据集说明</strong> 本数据集已完成数据清洗与重复值剔除，所有数据均为分类特征。 <strong>开发初衷</strong> 本数据集上传至U-BRITE平台，用于"DRG_DEPOT"2023年夏季团队项目，旨在构建R2G数据集，该数据集可实现药物与其药物靶点（基因→蛋白质即药物靶点）的映射关联。 <strong>致谢</strong> Freshour SL、Kiwala S、Cotto KC、Coffman AC、McMichael JF、Song JJ、Griffith M、Griffith OL、Wagner AH. 《药物-基因相互作用数据库（DGIdb 4.0）与开放众包资源的整合》. 《核酸研究》（Nucleic Acids Res.）, 2021年1月8日;49(D1):D1144-D1151. DOI: 10.1093/nar/gkaa1084. PMID: 33237278; PMCID: PMC7778926. 官方网址：https://www.dgidb.org/ <strong>U-BRITE 最后更新日期</strong>：2023年6月9日