Table 1_Global, regional, national epidemiology and trends of Parkinson’s disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021.docx

AimsIn light of the escalating global incidence of Parkinson’s disease and the dearth of therapeutic interventions that can alter the disease’s course, there exists an urgent necessity to comprehensively elucidate and quantify the disease’s global burden.
MethodsThis study analyzed the incidence, prevalence, and disability-adjusted life years (DALYs) of Parkinson’s disease at global, regional, and national levels based on the Global Burden of Disease Study 2021. Bayesian age-period cohort (BAPC) analysis was used to predict the burden in Parkinson’s disease from 2022 to 2035.
ResultsIn 2021, 11.77 million people worldwide had Parkinson’s disease. Age-standardized rates of incidence, prevalence, and DALYs increased to 15.63/100,000, 138.63/100,000, and 89.59/100,000. The burden of Parkinson’s disease were higher in males than in females, and showed an increase and then a slight decrease with age. The disease burden was highest in East Asia. BAPC projection showed an increase in all metrics by 2035 except for a slight decrease in the age-standardized DALYs rates.
ConclusionThe global burden of Parkinson’s disease has risen over the past 32 years, and there is a need to focus on key populations, as well as to improve health policies to prevent and treat Parkinson’s disease.

研究目的：鉴于全球帕金森病（Parkinson’s disease）发病率持续攀升，且当前缺乏可改变疾病进程的治疗干预手段，亟需全面阐明并量化该疾病的全球疾病负担。
研究方法：本研究基于《2021年全球疾病负担研究》（Global Burden of Disease Study 2021），分析了全球、区域及国家层面的帕金森病发病率、患病率与伤残调整生命年（disability-adjusted life years, DALYs）；采用贝叶斯年龄-时期-队列（Bayesian age-period cohort, BAPC）分析模型，对2022至2035年的帕金森病疾病负担进行预测。
研究结果：2021年，全球共有1177万帕金森病患者。年龄标化后的发病率、患病率及伤残调整生命年率分别升至15.63/10万、138.63/10万与89.59/10万。帕金森病疾病负担在男性群体中高于女性，且随年龄增长呈现先升高后小幅下降的趋势。东亚地区的疾病负担位居全球之首。贝叶斯年龄-时期-队列模型预测结果显示，至2035年，除年龄标化伤残调整生命年率出现小幅下降外，其余各项指标均将呈现上升态势。
研究结论：过去32年间，帕金森病的全球疾病负担持续上升，亟需重点关注关键人群，并完善卫生政策以推进帕金森病的预防与治疗工作。