Supplementary Material for: Impact of Socioeconomic Status and Ethnicity on Melanoma Presentation and Recurrence in Caucasian Patients

<b><i>Objectives:</i></b> The impact of ethnicity and the socioeconomic status (SES) among Caucasians is not well studied. Here, we examine the impact of income on melanoma presentation and prognosis within a Caucasian cohort, accounting for ethnicity, as some reports suggest increased melanoma incidence in Ashkenazi Jewish (AJ) <i>BRCA</i> mutation carriers. <b><i>Methods:</i></b> We studied prospectively enrolled primary melanoma patients at New York University. SES data were estimated using United States' Census Bureau data and patient zip codes. We evaluated associations between ethnicity, SES, and baseline characteristics using the χ² test and multivariate logistic regression. We compared survival distributions using Kaplan-Meier curves, log-rank tests, and Cox proportional hazard ratios. <b><i>Results:</i></b> Of the 1,339 enrolled patients, AJ represented 32% (n = 423). Apart from AJ being older at presentation (p &lt; 0.001), no significant differences were observed in baseline characteristics between ethnic groups. Patients with a median household income (MHI) lower than the median of the cohort were significantly more likely to present with advanced stages (p &lt; 0.001) compared to patients with a higher MHI. Shorter overall (p = 0.016) and post-recurrence survival (p = 0.042) was also observed in patients from lower-income households. <b><i>Conclusion:</i></b> Data suggest that disparities in melanoma presentation in Caucasians stratify according to income independent of ethnic background.

<b><i>研究目的：</i></b> 高加索人群中种族与社会经济地位（socioeconomic status, SES）的相关影响尚未得到充分研究。本研究针对高加索队列人群，探讨收入水平对黑色素瘤（melanoma）首诊表现与预后的影响，并校正种族因素——既往有研究报道，德系犹太裔（Ashkenazi Jewish, AJ）BRCA基因突变携带者的黑色素瘤发病率更高。<b><i>研究方法：</i></b> 本研究纳入纽约大学前瞻性入组的原发性黑色素瘤患者。利用美国人口普查局数据结合患者邮政编码估算其社会经济地位水平。采用卡方（χ²）检验与多因素logistic回归分析种族、社会经济地位与患者基线特征之间的关联；采用Kaplan-Meier曲线、对数秩检验及Cox比例风险模型对各组生存分布进行比较。<b><i>研究结果：</i></b> 本研究共纳入1339名患者，其中德系犹太裔占比32%（n=423）。除德系犹太裔患者首诊时年龄更大（p<0.001）外，不同种族组间的其余基线特征均无显著差异。与家庭中位收入（median household income, MHI）高于本队列中位水平的患者相比，家庭中位收入低于本队列中位水平的患者更易以晚期分期首诊（p<0.001）；低收入家庭患者的总生存期（p=0.016）及复发后生存期（p=0.042）均显著更短。<b><i>研究结论：</i></b> 本研究数据表明，高加索人群中黑色素瘤首诊相关的差异与收入水平相关，且不受种族背景影响。