Influenza breakthrough infection in vaccinated mice is characterized by non-pathological lung eosinophilia.

The authors previously reported a dose-dependent recruitment of eosinophils to the lungs of mice vaccinated with alum-adjuvanted trivalent inactivated influenza vaccine (TIV) following a sublethal, vaccine-matched H1N1 challenge. Herein, the authors conducted the investigations to phenotype the lung eosinophils observed in their model of influenza breakthrough infection.

作者此前曾报道，经铝佐剂三价灭活流感疫苗（TIV）免疫的小鼠，在接受亚致死剂量的疫苗匹配型H1N1病毒攻毒后，肺部会出现剂量依赖性的嗜酸性粒细胞（eosinophils）募集现象。本研究中，作者针对该流感突破感染模型中观察到的肺部嗜酸性粒细胞，开展了表型分型相关研究。