Seurat more cells A.9

<strong>seurat v3 object </strong> <br> <strong>ASSAYS:</strong> ADT: Antibody expression data RNA: mRNA expression data <br> <strong>DIMENSIONALITY REDUCTION</strong> projAML: Data was projected on the main AML dataset from Cohorts A and B. pca: pca computed on the 2000 most variable features umap: umap computed from first 15 principal components <br> <strong>METADATA</strong> patient: Patient ct: Projected cell type (Triana et al., 2021) ct_simple: Simplified projected celltype batch: Cells come either from total bone marrow or CD34+ enrichment using FACS proj_cluster: Projected cluster from main AML dataset leukemia_prob: CloneTracer leukemia probability status: Binarized status (healthy, pre-leukemic, leukemic, unsure) dormancy_score: score assessing the dormancy of cells based on Zhang 2021 and Cabezas-Wallscheid 2017 gene lists.

<strong>Seurat v3 对象（Seurat v3 object）</strong> <br> <strong>实验检测（ASSAYS）</strong>：ADT：抗体表达数据；RNA：mRNA（信使RNA）表达数据 <br> <strong>降维分析（DIMENSIONALITY REDUCTION）</strong>：projAML：数据已投影至队列A与队列B的核心急性髓系白血病（AML）数据集；pca：基于2000个最具变异性的特征计算得到的主成分分析（PCA）；umap：基于前15个主成分计算得到的均匀流形近似与投影（UMAP） <br> <strong>元数据（METADATA）</strong>：patient：患者信息；ct：预测细胞类型（Triana等，2021）；ct_simple：简化版预测细胞类型；batch：细胞来源为全骨髓或经荧光激活细胞分选（FACS）富集的CD34+细胞群；proj_cluster：核心AML数据集的预测聚类结果；leukemia_prob：CloneTracer算法计算的白血病发生概率；status：二分类状态（健康、前白血病、白血病、不确定）；dormancy_score：基于Zhang等2021年与Cabezas-Wallscheid等2017年的基因列表，评估细胞休眠状态的评分。