Redox-Neutral Indole Annulation Cascades

Aminobenzaldehydes react with indoles in an unprecedented cascade reaction. This acid-catalyzed redox-neutral annulation proceeds via a condensation/1,5-hydride shift/ring-closure sequence. Polycyclic azepinoindoles and related compounds are obtained in a single step with good to excellent yields.

氨基苯甲醛（Aminobenzaldehydes）与吲哚（indoles）可发生前所未有的级联反应。该酸催化的氧化还原中性环化反应经由缩合/1,5-氢迁移/环合的串联序列进行，可一步合成多环氮杂卓并吲哚类（polycyclic azepinoindoles）及相关化合物，产物收率良好至优异。