CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor APNEA (Compound 9)

CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor APNEA (Compound 9) Descriptor: 1,2-ETHANEDIOL, DNA Strand 1, DNA Strand 2, ... Authors: Horton, J.R, Zhou, J, Cheng, X. Deposit date: 2022-05-22 Release date: 2023-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence. J.Med.Chem., 66, 2023

CamA腺嘌呤甲基转移酶与同源底物DNA及抑制剂APNEA（化合物9）的复合物结构描述：1,2-乙二醇、DNA链1、DNA链2…… 作者：Horton, J.R.、Zhou, J、Cheng, X. 提交日期：2022-05-22 发布日期：2023-01-11 最后修改日期：2023-10-25 实验方法：X射线衍射（分辨率2.81 Å） 引用文献：《系统性设计腺苷类似物作为艰难梭菌特异性DNA腺嘌呤甲基转移酶抑制剂》，该酶为正常孢子形成与持续性感染所必需，发表于《J.Med.Chem.》，2023年，第66卷。