Sex-specific chromatin accessibility profiling in human PBMCs

We used ATAC-seq to profile the chromatin accessibility differences between sexes. We investigated the chromatin states of the PBMCs of twenty individuals, with an equal distribution of males and females, controlled for age (18-45 years old) and ethnicity (Caucasian). We examined chromatin accesibility using ATAC-seq in the PBMCs of twenty individuals.本研究采用转座酶可及性染色质测序（ATAC-seq）解析不同性别间的染色质可及性差异。我们针对二十名个体的外周血单个核细胞（PBMCs）的染色质状态开展分析，该队列男女比例均衡，且校正了年龄（18~45岁）与种族（高加索人）两项混杂因素。本研究通过ATAC-seq对二十名个体的外周血单个核细胞的染色质可及性进行了检测。