LFP signals of brain injured anesthetized animals undergoing closed-loop intracortical stimulation

Activity dependent stimulation (ADS) is a closed loop stimulation technique whose neurophysiological effects are not deeply investigated. Here we explored how Local field potentials (LFP) are impacted by a focal ischemic lesion and, subsequently, by an ADS treatment. Intracortical microelectrode arrays (A4x4-3mm-100-125-177 standard NeuroNexus) were implanted in the rostral forelimb area (RFA) and in the primary somatosensory area (S1) of anaesthetized rats. An ischemic injury was induced in the caudal forelimb area through microinjections of Endothelin-1.The dataset is divided in different phases (as depicted in figure) and two groups: ADS recieved treatment while C recieved sham. Pre-Post lesion data is availabel only for C.

活动依赖性刺激（Activity dependent stimulation, ADS）是一种闭环刺激技术，其神经生理学效应尚未得到深入研究。本研究探讨了局灶性缺血性损伤以及后续活动依赖性刺激治疗对局部场电位（Local field potentials, LFP）的影响。实验中将皮层内微电极阵列（A4x4-3mm-100-125-177 standard NeuroNexus）植入麻醉大鼠的前肢前区（rostral forelimb area, RFA）与初级躯体感觉皮层（primary somatosensory area, S1）。通过显微注射内皮素-1（Endothelin-1）在前肢后区诱导缺血性损伤。本数据集分为不同阶段（如图所示）与两组：ADS组接受活动依赖性刺激治疗，C组接受假手术。仅C组可获取损伤前后的相关数据。