Transcriptome Effects of the knockout of Intraflagellar Transport 88 gene in mice Mitral leaflets

The gene Ift88 is a gene critical for primary cilium biogenesis, the objective this study was to determine the transcriptome changes in Mitral leaflets in the absence of the gene. Overall design: Examination of transcriptome changes in an in vivo model organism knockout of the gene Ift88.

基因Ift88是调控初级纤毛（primary cilium）生物发生的关键基因，本研究旨在明确该基因缺失条件下二尖瓣叶的转录组（transcriptome）变化。整体实验设计：采用Ift88基因敲除的体内模式生物模型，对该基因缺失后的转录组变化进行检测分析。