Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth

These files contain the raw images and dataset used to generate Figures 1A, 5 (panels B, C, and G), 6 (panels A, D, E and F), and S3A of the article titled “Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth” by A.M. Gasparri, A. Pocaterra, B. Colombo, G. Taiè, C. Gnasso, A. Gori, F. Pozzi, A. Smith, F. Magni, A. Ugolini, M. Doglio, M.C. Bonini, A. Mondino, A. Corti, and C. Curnis, published in J Exp Clin Cancer Res 44, 88 (2025). https://doi.org/10.1186/s13046-025-03352-4

The research leading to these findings was funded by Associazione Italiana per la Ricerca sul Cancro (AIRC) under IG 2019 – ID. 23470 project – P.I. Angelo Corti; Fondazione AIRC 5 per Mille 2019 program (ID. 22737), P.I. MC Bonini, Group Leader A. Corti and A. Mondino; collectively supported by the national funding organizations under the framework of the ERA-NET TRANSCAN-3 initiative (ReachGlio project, ID: TRANSCAN2022-784-017 – Italian Ministry of Health ID: ERP-2022-23683648 to F. Curnis); and National Recovery and Resilience Plan (NRRP), M6/C2_CALL 2023 (project: POC-2023-12377318 to F. Curnis) funded by the European Union – NextGenerationEU.

本数据集包含用于生成论文《使用嗜铬粒蛋白A衍生肽阻断αvβ6和αvβ8整合素（αvβ6 and αvβ8 integrins）可抑制肿瘤内转化生长因子β（Transforming Growth Factor β, TGFβ）激活并抑制肿瘤生长》的原始图像与数据集文件，该论文作者为A.M. Gasparri、A. Pocaterra、B. Colombo、G. Taiè、C. Gnasso、A. Gori、F. Pozzi、A. Smith、F. Magni、A. Ugolini、M. Doglio、M.C. Bonini、A. Mondino、A. Corti与C. Curnis，发表于《实验与临床癌症研究杂志》（*Journal of Experimental & Clinical Cancer Research*, J Exp Clin Cancer Res）2025年，第44卷第88页，DOI: 10.1186/s13046-025-03352-4。本数据集对应的生成图表包括图1A、图5（B、C、G子图）、图6（A、D、E、F子图）以及补充图S3A。

本研究相关成果得到以下资助：意大利癌症研究协会（Associazione Italiana per la Ricerca sul Cancro, AIRC）IG 2019项目（编号23470，项目负责人为Angelo Corti）；AIRC 5‰ 2019计划（编号22737，项目负责人为M.C. Bonini，团队负责人为A. Corti与A. Mondino）；在ERA-NET TRANSCAN-3倡议框架下由多国国家资助机构联合支持的ReachGlio项目（项目编号：TRANSCAN2022-784-017，意大利卫生部配套编号ERP-2022-23683648，资助方为F. Curnis）；以及由欧盟下一代欧盟（NextGenerationEU）资助的国家恢复与韧性计划（National Recovery and Resilience Plan, NRRP）M6/C2批次2023年征集项目（项目编号：POC-2023-12377318，资助方为F. Curnis）。