Pd/C-Catalyzed Carbonylative Synthesis of α‑Carbonyl-α′-Amide Sulfoxonium Ylides from Azides

The synthesis of
α-carbonyl-α′-amide sulfoxonium
ylides by Pd/C-catalyzed carbonylative transformation of azides with
α-carbonyl sulfoxonium ylides has been studied. This method
offers a direct approach to produce synthetically useful α-carbonyl-α′-amide
sulfoxonium ylides in high efficiency. By using readily available
substrates, 39 examples of products were prepared in good yields with
outstanding functional group compatibility. An example of converting
the obtained ylide into the corresponding 1,3-dicarbonyl compound
has been given as well.

本研究针对钯碳（Pd/C）催化叠氮化物与α-羰基锍叶立德（α-carbonyl sulfoxonium ylides）的羰基化转化反应，合成α-羰基-α′-酰胺锍叶立德（α-carbonyl-α′-amide sulfoxonium ylides）的过程展开了系统探究。该方法为高效制备具备合成应用价值的α-羰基-α′-酰胺锍叶立德提供了直接途径。通过使用易得底物，我们以良好收率获得了39个目标产物，且该反应具有出色的官能团兼容性。此外，本研究还展示了一例将所得锍叶立德转化为对应1,3-二羰基化合物的应用实例。