Top gene sets enriched for hypermethylated genes.

Gene set enrichment analysis of genes near DMRs that are hypermethylated in severe SS cases relative to mild SS cases. Candidate gene sets include GO gene sets from the Molecular Signatures Database (30), genes known to harbor differentially-methylated CpG sites between SS cases and non-cases (SS DMP genes) (9), and genes known to be differentially expressed between SS cases and healthy controls (SS DE genes) (57). n = number of overlapping genes; adj. p-value = Benjamini-Hochberg adjusted p-value.
(XLSX)

针对相较于轻度干燥综合征（Sjögren's Syndrome，SS）患者呈现高甲基化的差异甲基化区域（Differentially Methylated Regions，DMR）邻近基因开展基因集富集分析。候选基因集涵盖来自分子特征数据库（Molecular Signatures Database，MSigDB）的基因本体（Gene Ontology，GO）基因集（30）、已知在干燥综合征患者与非患者之间携带差异甲基化CpG位点的基因（SS DMP基因）（9），以及已知在干燥综合征患者与健康对照者间存在差异表达的基因（SS DE基因）（57）。其中n代表重叠基因的数量；校正p值（adj. p-value）为经Benjamini-Hochberg校正后的p值。(XLSX)