Supplementary Material for: Global trends and hotspots in the association between chronic kidney disease and cardiovascular diseases: a bibliometric analysis from 2010 to 2023

Introduction
This study endeavors to evaluate the distribution patterns and research frontiers within the international literature on the association between chronic kidney disease and cardiovascular diseases in the medical field, through bibliometric analysis and visualized information.

Methods
The Web of Science Core Collection database was selected as the data source from 2010 to 2023, and articles related to the association between chronic kidney disease and cardiovascular diseases were retrieved. The article data was analyzed through CiteSpace for bibliometric mapping, involving the examination of keywords, references, country/region distributions, and institutional contributions to identify and understand the evolving research dynamics and frontiers in this interdisciplinary field.

Results
A total of 2936 publications on the association between chronic kidney disease and cardiovascular diseases were included. The country with the most publications was USA (n=904), and the institution with the most publications was University of Pennsylvania (n=116). The most frequent keywords were chronic kidney disease (n=2194), cardiovascular disease (n=1188), and mortality (n=604). The top 20 keywords and top ten references that burst during 2010 to 2023 were listed.

Conclusion
The association between chronic kidney disease and cardiovascular diseases has sparked extensive research, particularly in high-prevalence areas. From 2010 to 2023, publications on the association between chronic kidney disease and cardiovascular diseases show a linear increase. Current research hotspots and frontiers are mainly in cardiovascular-kidney-metabolic syndrome; innovative therapies and drug impact; gut microbiome; mendelian randomization analysis. Overall, our study offers a comprehensive scientometric analysis of the association between chronic kidney disease and cardiovascular diseases, providing valuable insights for both researchers and healthcare professionals in the field.

引言
本研究旨在通过文献计量分析（bibliometric analysis）与可视化分析手段，评估医学领域内慢性肾脏病（chronic kidney disease）与心血管疾病（cardiovascular diseases）相关研究的国际文献分布规律与研究前沿。

研究方法
本研究选取2010至2023年的Web of Science 核心合集（Web of Science Core Collection）数据库作为数据源，检索与慢性肾脏病和心血管疾病相关的文献。随后采用CiteSpace对检索得到的文献数据进行文献计量可视化制图分析，涵盖关键词、参考文献、国家/地区分布及机构贡献度等维度，以厘清该交叉学科领域的研究动态演化脉络与前沿方向。

研究结果
本研究共纳入2936篇与慢性肾脏病和心血管疾病相关的文献。其中发文量最多的国家为美国（n=904），发文量最多的机构为宾夕法尼亚大学（n=116）。出现频次最高的关键词依次为慢性肾脏病（n=2194）、心血管疾病（n=1188）与死亡率（n=604）。本研究同时列出了2010至2023年间出现频次前20的关键词以及突现强度前10的参考文献。

结论
慢性肾脏病与心血管疾病的关联研究已引发广泛关注，在高患病率领域尤为突出。2010至2023年间，相关领域的发文量呈线性增长趋势。当前的研究热点与前沿主要集中于心血管-肾脏-代谢综合征（cardiovascular-kidney-metabolic syndrome）、创新疗法与药物影响、肠道菌群（gut microbiome）以及孟德尔随机化分析（Mendelian randomization analysis）。本研究对慢性肾脏病与心血管疾病的关联开展了全面的科学计量分析，可为该领域的研究人员与医疗从业者提供具有参考价值的见解。